A Formal Synthesis of Lavendamycin Methyl Ester, Nitramarine, and Their Analogues: A Povarov Approach
β Scribed by Ramesh, Subburethinam; Nagarajan, Rajagopal
- Book ID
- 118143120
- Publisher
- American Chemical Society
- Year
- 2012
- Tongue
- English
- Weight
- 747 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0022-3263
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A total synthesis of (+)-methyl nonactate from a chiral synthon obtained by enantioselective enzymatic transesterification is described. This new approach involves stereoselective reactions of aldolisation, reduction and intramolecular Michael addition and appears to be quite general since it could
A General and Stereoselective Approach to Nonactate Esters and Isomers: A Versatile Synthesis of (+)-Methyl Nonactate. -The title compound (XIII), which is a subunit of the macrotetrolide antibiotic nonactin, is stereoselectively synthesized from the chiral hydroxyacetate (I) in 11 steps and 6.4% o