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A formal synthesis of aspartame via the oxaziridine - amide rearrangement

✍ Scribed by Pierre Duhamel; Bertrand Goument; Jean - Christophe Plaquevent

Book ID
104227624
Publisher
Elsevier Science
Year
1987
Tongue
French
Weight
114 KB
Volume
28
Category
Article
ISSN
0040-4039

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✦ Synopsis

A formal synthesis of the dipeptide sweetener aspartame via the oxaziridineamide rearrangement is reported. Thus, the peptidic oxaziridine 4 was prepared and was photochemically isomerized into the aspartame precursor I-As part of our programme for the non classical creation of peptide bonds, we recently described a non isohypsic method (1) essentially based on oxaziridine -amide isomerization (2). Here we wish to report a formal synthesis of the dipeptide sweetener aspartame by this method.

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