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A formal stereoselective synthesis of a hydroxyethylene dipeptide isostere

✍ Scribed by Jean-François Peyrat; Christophe Chaboche; Bruno Figadère; André Cavé


Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
179 KB
Volume
36
Category
Article
ISSN
0040-4039

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Synthesis of hydroxyethylene and ketomet
✍ Mark W. Holladay; Daniel H. Rich 📂 Article 📅 1983 🏛 Elsevier Science 🌐 French ⚖ 210 KB

A general stereo-directed synthesis of "ketomethylene" and "hydroxyethylene" dipeptide isosteres is reported. Peptides containing the amino acids, (2&%)-5-amino-4-oxo-2,8dimethyloctanoic acid (the "ketomethylene" analog of L-Leu-L-Ala), and (2&,5z)-5-amino-4-hydroxy-2,8-dimethyloctanoic acid (the "h