A recyclable fluorous labeled THP protecting group has been developed that allows for simple purification of small molecules by liquid-liquid extraction with FC-72/MeCN, and of larger or more polar molecules by solid phase extraction with fluorous reverse phase silica gel. In addition, we report a n
A Fluorous Phosphate Protecting Group with Applications to Carbohydrate Synthesis
β Scribed by Liu, Lin; Pohl, Nicola L. B.
- Book ID
- 120089471
- Publisher
- American Chemical Society
- Year
- 2011
- Tongue
- English
- Weight
- 839 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1523-7060
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π SIMILAR VOLUMES
Synthesis and Applications of a Fluorous THP Protective Group. -A variety of alcohols (IX) can be protected with a fluorous labeled THP protecting group using the Cp 2 ZrCl 2 -AgClO 4 reagent system to activate the sulfoxide (VII). The protected alcohols (X) can be easily purified by liquid-liquid
A readily recyclable, fluorous alkoxy ethyl ether protecting group has been developed that allows for simple purification of small to medium-sized organic molecules by liquid-liquid extraction with FC-72/organic/aqueous solvents. The precursor vinyl ether 3 can be prepared in large quantity in a str