A Fluorometric Screening Assay for Drug Efflux Transporter Activity in the Blood-Brain Barrier
โ Scribed by Corbin J. Bachmeier; Donald W. Miller
- Publisher
- Springer US
- Year
- 2005
- Tongue
- English
- Weight
- 184 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0724-8741
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract ## Aims The objective of the present study was to evaluate drug efflux transporter interactions of darifenacin and examine the impact of such transporter interactions on darifenacin permeability in an __in vitro__ model of the bloodโbrain barrier (BBB) and bloodโocular barrier (BOB).
A relatively simple, widely applicable, and robust in vitro method of predicting blood-brain barrier (BBB) permeability to central nervous system-acting drugs is an increasing need. A cell-based model offers the potential to account for transcellular and paracellular drug diffusional processes, meta