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A Flexible Synthesis of Indoline, Indolizidine, and Pyrrolizidine Derivatives

✍ Scribed by Igor Bytschkov; Holger Siebeneicher; Sven Doye


Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
344 KB
Volume
2003
Category
Article
ISSN
1434-193X

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Asymmetric synthesis of hydroxylated pyr
✍ Patricio Guerreiro; Virginie Ratovelomanana-Vidal; Jean-Pierre GenΓͺt πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 95 KB πŸ‘ 1 views

The enantioselective ruthenium promoted hydrogenation of beta-keto ester, derived from (S)- or (R)-proline and (S)-pipecolic acid, provided a new efficient route to hydroxylated pyrrolizidine or indolizidine ring systems in diastereomeric excesses up to 99%. A practical synthesis of (+)-alpha-conhyd