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A Flexible Route to (5 R )-Thiolactomycin, a Naturally Occurring Inhibitor of Fatty Acid Synthesis

โœ Scribed by McFadden, Jill M.; Frehywot, Gojeb L.; Townsend, Craig A.


Book ID
124092177
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
76 KB
Volume
4
Category
Article
ISSN
1523-7060

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A flexible non-amino acid-based formal a
โœ Bi-Yan He; Tian-Jun Wu; Xian-Yong Yu; Pei-Qiang Huang ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 464 KB

A flexible non-amino acid-based formal asymmetric synthesis of naturally occurring antimicrobial (2R,3S)-2-aminotetradeca-5,7-dien-3-ol is reported. The method features a flexible and highly regioselective Grignard addition to (S)-malimide followed by a trans-diastereoselective reductive deoxygenati