## Abstract The benzannulated spiroketal cores (IV) of berkelic acid are readily produced by HornerโWadsworthโEmmons olefination and a oneโpot hydrogenation/deprotection/cyclization process.
A Flexible Approach to 6,5-Benzannulated Spiroketals
โ Scribed by Zoe E. Wilson; Jonathan G. Hubert; Margaret A. Brimble
- Book ID
- 102831402
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 610 KB
- Volume
- 2011
- Category
- Article
- ISSN
- 1434-193X
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โฆ Synopsis
Abstract
A novel route to simple 6,5โbenzannulated spiroketal analogues has been developed. A convergent HornerโWadsworthโEmmons olefination enabled ready assembly of the spiroketal precursors. Use of a benzyl protecting group strategy enabled an efficient oneโpot hydrogenation/deprotection/spiroketalisation process to be employed providing a robust method to access a range of substituted aromatic monobenzannulated spiroketals.
๐ SIMILAR VOLUMES
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