Levodopa-induced dyskinesia can result in significant functional disability and reduced quality of life in patients with Parkinson's disease (PD). The goal of this study was to determine if the addition of once-daily ropinirole 24hour prolonged-release (n 5 104) in PD patients not optimally controll
A Five-Year Study of the Incidence of Dyskinesia in Patients with Early Parkinson's Disease Who Were Treated with Ropinirole or Levodopa
β Scribed by Rascol, Olivier; Brooks, David J.; Korczyn, Amos D.; De Deyn, Peter P.; Clarke, Carl E.; Lang, Anthony E.
- Book ID
- 120000778
- Publisher
- Massachusetts Medical Society
- Year
- 2000
- Tongue
- English
- Weight
- 114 KB
- Volume
- 342
- Category
- Article
- ISSN
- 0096-6762
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The efficacies of ropinirole and levodopa were compared after 6 months of treatment in a planned interim analysis of a 5-year, double-blind, randomized, multicenter study of patients with early Parkinson's disease requiring dopaminergic therapy. The percentage of improvement in the Unified Parkinson
## Abstract To assess the safety and efficacy of sumanirole, a highly selective dopamine agonist, versus placebo and demonstrate its noninferiority to ropinirole, 614 patients with early Parkinson's disease (PD) were treated with sumanirole, 1 to16 mg/day; ropinirole, 0.75 to 24 mg/day; or placebo.