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A feasibility study of the use of the AutoPap screening system as a primary screening and location-guided rescreening device

✍ Scribed by Confortini, Massimo ;Bonardi, Lucia ;Bulgaresi, Paolo ;Cariaggi, Maria Paola ;Cecchini, Silvia ;Ciatto, Stefano ;Cipparrone, Ida ;Galanti, Laura ;Maddau, Cristina ;Matucci, Marzia ;Rubeca, Tiziana ;Troni, Grazia Maria ;Turco, Patricia ;Zappa, Marco ;Carozzi, Francesca

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 84 KB
Volume: 99
Category: Article
ISSN: 0008-543X
DOI: 10.1002/cncr.11077

No coin nor oath required. For personal study only.

✦ Synopsis

Background:

The autopap 300 qc system (tripath imaging, inc., burlington, nc) is an automated device that was designed to screen conventionally prepared cervical smears and, more recently, thin-layer slide preparations. the system has been tested in large clinical trials.

Methods:

A total of 14,145 cervical smears obtained from participants in the florence screening program were eligible for the study. smears were processed first with the autopap system and were classified into three different categories: 1) no further review (nfr), 2) review, and 3) process review (pr). conventional manual reading was performed by 10 experienced cytopathologists.

Results:

After autopap processing, 2398 smears were classified as nfr (16.9%), and 1818 smears were classified as pr (12.8%). overall, there were 188 inadequate smears (1.3%) at conventional review and 125 inadequate smears (0.88%) at autopap review. six-month repeat smears were prompted by 330 conventional reviews (2.3%) and by 222 autopap reviews (1.56%). similarly, referral to colposcopy was prompted by 179 conventional reviews (1.2%) and by 147 autopap reviews (1.0%). overall, 32 patients were diagnosed with high-grade cervical intraepithelial neoplasia as a result of assessment. conventional reading detected 31 patients (28 patients were referred for colposcopy, and 3 patients were referred for repeat cytology), and the autopap system detected 30 patients (27 patients were referred for colposcopy, and 3 patients were referred for repeat cytology).

Conclusions:

The current experience suggested that conventional reading and autopap reading of cervical smears had essentially the same sensitivity, with slightly greater specificity for the autopap system. thus, comparisons of the autopap system and conventional reading should focus mainly on cost analysis.

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