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A family with X-linked deafness showing linkage to the proximal Xq region of the X chromosome

✍ Scribed by David Robinson; Margaret Lamont; Greta Curtis; Denis C. Shields; Peter Phelps

Publisher
Springer
Year
1992
Tongue
English
Weight
260 KB
Volume
90
Category
Article
ISSN
0340-6717

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✦ Synopsis

Linkage analysis has been carried out in a family with severe congenital sensorineural deafness with a structural abnormality of the inner ear. Recombinations show the gene responsible for deafness in this family to lie between the loci DXS255 (Xp11.22) and DXS94 (Xq22). Close linkage was found to locus DXS159 (cpX289) in Xq12, with a LOD score of 3.155 and 0 recombination. This location is consistent with other linkage studies of X-linked deafness.

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