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A Family-based Genetic Association Study of Variants in Estrogen-metabolism GenesCOMTandCYP1B1and Breast Cancer Risk

✍ Scribed by Habibul Ahsan; Yu Chen; Alice S. Whittemore; Muhammad G. Kibriya; Irina Gurvich; Ruby T. Senie; Regina M. Santella

Book ID
111575052
Publisher
Springer US
Year
2004
Tongue
English
Weight
111 KB
Volume
85
Category
Article
ISSN
0167-6806

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## Abstract p21^Cip1^ and p27^Kip1^ are cyclin‐dependent kinase inhibitors, which can arrest cell proliferation and serve as tumor suppressors. Reduced protein expression of p21^Cip1^ and p27^Kip1^ was frequently observed in a subset of cancers, including breast cancer. In this study, we hypothesiz