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A facile synthesis of some substituted furopyrimidine derivatives
β Scribed by Jung In Pyo; So Ha Lee; Chan Seong Cheong
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2006
- Tongue
- English
- Weight
- 102 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0022-152X
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β¦ Synopsis
Abstract
Some substituted furopyrimidine derivatives are prepared in high yield in 4 steps, starting from the reaction of furoin (1,2βdi(furanβ2βyl)β2βhydroxyethanone) and malonitrile.
π SIMILAR VOLUMES
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## 3-Dicyanomethylene -3-phenylpropionitrib coupled with diazotized aromatic amines (Ar-NHJ to afford hydrazono derivatives. The latter (Ar = C a 5 , 4-C H 3 C a 4 , 4-CH@c&, and 4-C1C6H4) were readily cyclized upon reflux in aqueous NaOH to 3(2H) pyridazinimine derivatives, which were readily tra