A facile synthesis of simple alkaloids—synthesis of 2,3-polymethylene-4(3H)-quinazolinones and related alkaloids

✍ Scribed by Eung Seok Lee; Jae-Gyu Park; Yurngdong Jahng

• Book ID: 104253020
• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 204 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(03)00080-7

✦ Synopsis

An efficient procedure for preparation of the simple alkaloids, 2,3-polymethylene-4(3H)-quinazolinones, luotonin A, tryptanthrin, and rutaecarpine has been established by the reaction of lactam-HCl salts with POCl 3 followed by cyclization with methyl anthranilate.