A facile synthesis of optically pure valerolactone and β-hydroxy valerolactone from a common sugar-derived precursor

✍ Scribed by Christos Papageorgiou; Claude Benezra

• Publisher: Elsevier Science
• Year: 1984
• Tongue: French
• Weight: 144 KB
• Volume: 25
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)81755-x

✦ Synopsis

Both title compounds were obtained in four steps from 2R, 3R-dihydroxy-4Rvalerolactone 2 readily available from D-ribonolactone. Chiral y-lactones are a common feature of many natural products. Among them, valerolactones 1 are the privileged target of a number of chiral syntheses'. The synthesis