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A Facile Synthesis of New 2-Carboxamido-3-carboxythiophene and 4,5,6,7-Tetrahydro-2-carboxamido-3-carboxythieno[2,3-c]pyridine Derivatives as Potential Endothelin Receptors Ligands.

✍ Scribed by Valeria Pittala; Maria Modica; Giuseppe Romeo; Luisa Materia; Loredana Salerno; Mariangela Siracusa; Alfredo Cagnotto; Ilario Mereghetti; Filippo Russo


Publisher
John Wiley and Sons
Year
2006
Weight
24 KB
Volume
37
Category
Article
ISSN
0931-7597

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Synthesis of 5-phenyl-5,6,7,8-tetrahydro
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## Abstract A new access to 5‐phenyl‐5,6,7,8‐tetrahydro‐1,6‐naphthyridines **25a‐28a** (n=1) and 5‐phenyl‐6,7,8,9‐tetrahydro‐5__H__‐pyrido[3,2‐__c__]azepines **25b‐28b** (n=2) has been developed by first preparing the functional pyridine moiety followed by intramolecular cyclization forming the par