A facile synthesis of indeno[1,2-b]chromanes catalyzed by scandium triflate

✍ Scribed by Jhillu S Yadav; B.V.Subba Reddy; Celine Parisse; Peter Carvalho; T.Prabhakar Rao

• Book ID: 104250863
• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 230 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)00440-9

✦ Synopsis

Scandium triflate efficiently catalyzes the cyclocondensation of o-hydroxybenzaldehydes with alkenes such as indene, styrene and allyltrimethylsilane in the presence of trimethyl orthoformate at ambient temperature to afford a new class of compounds, 2,4-disubstitued chromanes in high yields with high diastereoselectivity.