A facile synthesis of functionally complex isoxazole derivatives
✍ Scribed by N.R. Natale; Chorng-Shyr Niou
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- French
- Weight
- 177 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0040-4039
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## Abstract Isoxazole derivatives, 3‐sulfanilamido‐5‐methylisoxazole (I) and 3,3‐dimethyl‐1‐(5‐methyl‐3‐isoxazolylcarbonyl)‐urea (II), have been labelled with carbon‐14. The carbon‐14 label was incorporated into the C‐5 of the isoxazole ring to give (I) and (II) in 22.3% and 33.0% radiochemical yie
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## Abstract magnified image The several novel 3‐substituted phenyl isoxazole derivatives were prepared from substituted phenyl‐butan‐1,3‐dione. Their structures were confirmed by element analysis, IR, MS, and ^1^H NMR. X‐ray structure analysis indicated that the dihedral angles of the phenyl ring w