𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A facile synthesis of 5H-1-thia-3,5,6,8-tetraazaacenaphthylenes

✍ Scribed by Tumkevičius, Sigitas

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
303 KB
Volume
1995
Category
Article
ISSN
0947-3440

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Ethyl 5‐substituted 7‐(methylthio)‐5__H__‐1‐thia‐3,5,6,8‐ tetra‐azaacenaphthylene‐2‐carboxylates (5a‐f) representing a new heterocyclic system were prepared by acid‐catalyzed cyclocondensation of ethyl 5‐amino‐4‐(substituted amino)‐2‐(methylthio)thieno[2,3‐d]pyrimidine‐6‐carboxylates (3a‐f) with triethyl orthoformate. Compounds 3 were obtained by aminolysis of 4,6‐dichloro‐2‐(methylthio)pyrimidine‐5‐carbonitrile (1) affording 2 followed by base‐promoted cyclization with sodium ethyl thioglycolate.

📜 SIMILAR VOLUMES

Fused quinoline heterocycles VI: Synthes
Fused quinoline heterocycles VI: Synthesis of 5H-1-thia-3,5,6-triazaaceanthrylenes and 5H-1-thia-3,4,5,6-tetraazaaceanthrylenes
✍ Ramadan Ahmed Mekheimer; Kamal Usef Sadek; Hisham Ahmed Abd El-Nabi; Afaf Abd El 📂 Article 📅 2005 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 129 KB

Ethyl 3-amino-4-chlorothieno[3,2-c]quinoline-2-carboxylate (4) is a versatile synthon, prepared by reacting an equimolar amount of 2,4-dichloroquinoline-3-carbonitrile (1) with ethyl mercaptoacetate (2). Ethyl 5-alkyl-5H-1-thia-3,5,6-triazaaceanthrylene-2-carboxylates 9a-c, novel perianellated tetra