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A facile synthesis of 5-amino-[1,2,3]triazolo[5,1-a]isoquinoline derivatives through copper-catalyzed cascade reactions

โœ Scribed by Chen, Yunfeng; Zhou, Shilei; Ma, Shan; Liu, Wenqian; Pan, Zhiquan; Shi, Xiaodong


Book ID
121260299
Publisher
Royal Society of Chemistry
Year
2013
Tongue
English
Weight
722 KB
Volume
11
Category
Article
ISSN
1477-0520

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๐Ÿ“œ SIMILAR VOLUMES


Triazolopyridines. 19. Synthesis and rea
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Preparation and structure of salts and ylides derived from triazolo[l,5-a]quinoline 2 and triazolo[5,1 -a]isoquinoline 3 are described. Reactions with methyl propiolate of ylides 6-9 give pyrrolo[l,2-a]quinolines 13, 18 and pyrrolol2,1-a]isoquinolines 12, 19.

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Nucleophilic substitution of 5-bromotriazoloisoquinoline (3) and of 7-bromo-3-methyltriazolopyridine (6) proceeds readily to give a range of 5-substituted triazoloisoquinolines (4a)-(4e), and of 7-substituted triazolopyridines (7a)-(7h) respectively. Triazoloisoquinolines have been converted into 1,