A facile synthesis of 5-amino-[1,2,3]triazolo[5,1-a]isoquinoline derivatives through copper-catalyzed cascade reactions
โ Scribed by Chen, Yunfeng; Zhou, Shilei; Ma, Shan; Liu, Wenqian; Pan, Zhiquan; Shi, Xiaodong
- Book ID
- 121260299
- Publisher
- Royal Society of Chemistry
- Year
- 2013
- Tongue
- English
- Weight
- 722 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1477-0520
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๐ SIMILAR VOLUMES
Preparation and structure of salts and ylides derived from triazolo[l,5-a]quinoline 2 and triazolo[5,1 -a]isoquinoline 3 are described. Reactions with methyl propiolate of ylides 6-9 give pyrrolo[l,2-a]quinolines 13, 18 and pyrrolol2,1-a]isoquinolines 12, 19.
Nucleophilic substitution of 5-bromotriazoloisoquinoline (3) and of 7-bromo-3-methyltriazolopyridine (6) proceeds readily to give a range of 5-substituted triazoloisoquinolines (4a)-(4e), and of 7-substituted triazolopyridines (7a)-(7h) respectively. Triazoloisoquinolines have been converted into 1,