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A FACILE SYNTHESIS OF 3ß-ACETOXYLANOST-8-EN-24-ONE (24-KETOLANOSTERYL ACETATE)

✍ Scribed by Parish, Edward J.; Sun, Hang; Kizito, Stephen A.; Kaneshiro, Edna S.

Book ID
126667428
Publisher
Taylor and Francis Group
Year
1999
Tongue
English
Weight
165 KB
Volume
31
Category
Article
ISSN
0030-4948

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A facile synthesis of lanost-8-en-3β-ol-
A facile synthesis of lanost-8-en-3β-ol-24-one (24-ketolanosterol). An inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase
✍ Edward J. Parish; Hiroshi Honda; Sarawanee Chitrakorn; Frederick R. Taylor 📂 Article 📅 1988 🏛 Elsevier Science 🌐 English ⚖ 361 KB

A facile chemical synthesis of lanost-8-en-3 beta-ol-24-one (24-ketolanosterol) is described. This compound was found to be a potent inhibitor of 3-hydroxy-3-methylglutaryl (HMG) CoA reductase activity in cultured mouse L cells. The synthetic scheme developed in this study utilizes commercial lanost