A facile synthesis of 3,5-dimethyl-4-hydroxybenzaldehyde via copper-mediated selective oxidation of 2,4,6-trimethylphenol
โ Scribed by Xiaojiao Sun; Zaher M.A. Judeh; Basem F. Ali; Solhe F. Alshahateet
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 213 KB
- Volume
- 131
- Category
- Article
- ISSN
- 0920-5861
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๐ SIMILAR VOLUMES
Selective terminal oxidation of 3,3-dimethyl-4-pentenoates does occur under chloride-free Wacker conditions [Pd(OAc)2/02] in AcOH to give 5-acetoxy-3.3-dimethyl-4pentenoates ( 7) and their analogues (2. 8) in good yields. Successive cyclization of 7 and 8 at vapor phase pyrolysis on SiO2 affords '3,
Treatment of 5-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione with primary arylamines in CH 2 Cl 2 at rt gave 5-[(arylamino)(cyano)methylene]-2,2-dimethyl-1,3-dioxane-4,6-diones in excellent yields. The latter compounds were utilized for the preparation of 2-cyano-4-quino