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A facile synthesis and heteroannulation of thiazolopyrimidine and related heterocyclic systems

✍ Scribed by A. A. Aly

Publisher
Journal of Heterocyclic Chemistry
Year
2008
Tongue
English
Weight
347 KB
Volume
45
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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Reaction of pyrimidinylacetic acid 2 with different electrophilic and nucleophilic reagents gave annulated pyrimidine derivatives 3‐11, respectively. Compound 3 was transformed to pyrimidinylacetyl azide 12, which upon heterocyclization with active methylene compounds, acidic and basic reagents furnished functionally substituted heteroaromatic compounds 13‐21, respectively. The antimicrobial activity of some synthesized compounds was investigated. The structures of the synthesized derivatives were elucidated by elemental and spectral analyses.

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