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A Facile Stereocontrolled Synthesis of anti -α-(Trifluoromethyl)-β-amino Alcohols

✍ Scribed by Prakash, G. K. Surya; Mandal, Mihirbaran; Schweizer, Stefan; Petasis, Nicos A.; Olah, George A.


Book ID
126897696
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
64 KB
Volume
2
Category
Article
ISSN
1523-7060

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A facile and stereocontrolled synthesis
✍ Alessandra Maria Nocioni; Carmela Papa; Claudia Tomasini 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 215 KB

The diastereoselective synthesis of syn-a-alkyl a-hydroxy 13-amino acids 4a-h was easily accomplished by reaction of the sodium dianion of the corresponding anti a-alky113-benzoylamino acid methyl esters with iodine. The intermediate a-iodo derivatives spontaneously afforded c/s-oxazolines which, up