A facile solvent-free synthesis of 1-alkyl/aralkyl-2-(1-arylsulfonyl alkyl) benzimidazoles using “TBAB” as surface catalyst

✍ Scribed by P. K. Dubey; P.V.V. Prasada Reddy; K. Srinivas

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2010
• Tongue: English
• Weight: 134 KB
• Volume: 47
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.450

✦ Synopsis

Abstract

magnified image Reaction 2‐(α‐chloroalkyl)benzimidazoles 1 with aryl sulphinate sodium salt 2 under solvent‐free conditions in the presence of tetrabutylammonium bromide as surface catalyst, by simple physical grinding using mortar and pestle, gives 1__H__‐2‐(α‐arylsulfonylalkyl)benzimidazoles 3. The latter on treatment with alkylating agents under solvent‐free conditions results in 1‐alkyl/aralkyl‐2‐(α‐arylsulfonylalkyl)benzimidazoles 4. Alternatively, 4 can also be prepared directly from 1‐alkyl/aralkyl‐2‐(α‐chloroalkyl)benzimidazoles 5 by reaction with 2, which in turn could be prepared by reaction of 1 with alkylating agents under solvent‐free conditions and all these reactions are free from organic solvents including experimental procedures. J. Heterocyclic Chem., (2010).