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A facile regioselective synthesis of (5-amino-4-cyano-1h-imidazol-1-yl) benzoic acids

✍ Scribed by Síria A. Barros; M. Sameiro T. Gonçalves; Ana M. F. Oliveira-Campos; Fernanda R. P. Proença

Publisher: Journal of Heterocyclic Chemistry
Year: 2007
Tongue: English
Weight: 458 KB
Volume: 44
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570440103

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✦ Synopsis

Abstract

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A simple and efficient method was developped for the synthesis of 3‐(5‐amino‐4‐cyano‐1__H__‐imidazol‐1‐yl)‐4‐substituted benzoic acids 3. These compounds were isolated by intramolecular cyclisation of the corresponding 3‐{[(Z)‐2‐amino‐1,2‐dicyano‐vinyl]amino}methyleneaminobenzoic acids in the presence of base.

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