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A facile, regio- and stereo-selective synthesis of ganglioside GM3

โœ Scribed by Takatoshi Murase; Hideharu Ishida; Makoto Kiso; Akira Hasegawa


Book ID
107725820
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
800 KB
Volume
188
Category
Article
ISSN
0008-6215

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A facile regio- and stereo-selective syn
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Sialic acids',\* are well known as constituents of glycoproteins and glycolipids of cell membranes, and they play a role in biological recognition. It is also known that naturally occurring sialo compounds contain sialic acids in a-glycosidic linkage, except for CMP-N-acetylneuraminic acid. Therefo

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Mammals, birds, amphibians, and teleost fish all have similar brain gangliosides. These gangliosides are of the ganglio-series with predominantly, gangliotetraose, P-o-Gal-(1 + 3)-fl-D-GalNAc-(1 + +&o-Gal-( 1+ 4)-~-Gk, as the neutral oligosaccharide, though with a varying degree of sialylation. Sinc

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Gangliosides, sialic acid containing glycosphingolipids, are a class of structurally diverse molecules commonly present in vertebrate plasma membranes and especially enriched in nerve tissues\*. These membrane components are thought to be responsible for important physiological activities, and it is