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A facile preparation of α-hydroxy fatty acids

✍ Scribed by Florentina N. Muralidharan; V.B. Muralidharan


Book ID
107737049
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
388 KB
Volume
34
Category
Article
ISSN
0009-3084

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✍ Alessandra Maria Nocioni; Carmela Papa; Claudia Tomasini 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 215 KB

The diastereoselective synthesis of syn-a-alkyl a-hydroxy 13-amino acids 4a-h was easily accomplished by reaction of the sodium dianion of the corresponding anti a-alky113-benzoylamino acid methyl esters with iodine. The intermediate a-iodo derivatives spontaneously afforded c/s-oxazolines which, up