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A facile preparation of gem-difluorohomoallylic alcohols[1]

✍ Scribed by Zhen-Yu Yang; Donald J. Burton

Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
209 KB
Volume
44
Category
Article
ISSN
0022-1139

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✦ Synopsis

The reaction of 3-bromo-3,3-difluoropropene with zinc powder in THF at OΒ°C to room temperature in the presence of aldehydes and ketones provides a useful, easily scaled up route to gemdifluorohomoallylic alcohols. a,P-Unsaturated aldehydes and ketones give exclusively the 1,2-addition product. In all cases, only the a-gem-difluorohomoallyl regioisomer was observed.

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