A facile preparation of 2,6-diarylpyrazines
β Scribed by Guofeng Jia; Zhengming Lim; Yaoshu Zhang
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 171 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1042-7163
No coin nor oath required. For personal study only.
β¦ Synopsis
2,6-Diarylpyrazines were prepared in good yields by a novel method of condensing methoxycarbonylhydrazine with N,N-bis(arylcarbonylmethyl)-p-toluenesulfonamides, unsymmetrical derivatives of which were synthesized by a new (or different) procedure. The structures of these 2,6-diarylpyrazines were established by spectral data and X-ray diffraction analysis.
π SIMILAR VOLUMES
14ClFormaldehyde was used in a nucleophile-assisted iminium ion cyclization with N-benzyl-3-butynylamine to provide N-benzyl-4-iodo-I ,2,5,6-tetrahydr0[2,6-1~C2]pyridine. Palladium-catalyzed coupling of this vinyl iodide with the organozinc derivative 2 gave the corresponding 4arylated tetrahydropyr