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A facile one-pot synthesis of Nα-Z/Boc-protected S-linked 1,3,4-oxadiazole tethered peptidomimetics

✍ Scribed by Vommina V. Sureshbabu; B. Vasantha; G. Nagendra


Book ID
113930441
Publisher
Elsevier Science
Year
2012
Tongue
French
Weight
516 KB
Volume
53
Category
Article
ISSN
0040-4039

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A facile synthesis of N-Z/Boc-protected
✍ Ravi S. Lamani; G. Nagendra; Vommina V. Sureshbabu 📂 Article 📅 2010 🏛 Elsevier Science 🌐 French ⚖ 713 KB

Synthesis of 1,3,4-oxadiazole containing peptidomimetics is described by a p-TsCl/pyridine-mediated cyclization of the corresponding dipeptidyl thiosemicarbazides, which are readily prepared by coupling N-protected amino acid hydrazides with amino acid-derived isothiocyanato esters. Further, the pro