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A Facile Method for the Transformation of N -( tert -Butoxycarbonyl) α-Amino Acids to N -Unprotected α-Amino Methyl Esters

✍ Scribed by Chen, Bang-Chi; Skoumbourdis, Amanda P.; Guo, Peng; Bednarz, Mark S.; Kocy, Octavian R.; Sundeen, Joseph E.; Vite, Gregory D.

Book ID
121080319
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
59 KB
Volume
64
Category
Article
ISSN
0022-3263

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📜 SIMILAR VOLUMES

A facile method for the N-alkylation of
A facile method for the N-alkylation of α-amino esters
✍ W. Russell Bowman; Daniel R. Coghlan 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 853 KB

Monoalkylation of the a-amino group of or-amino acid derivatives can be facilitated using 2and 4-nitrophenylsulfonamide intermediates. The nitrophenylsulfonamides of a-amino esters can be alkylated using an equimolar amount of carbonate base and a variety of alkyl bromides. Ready removal of the nitr