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A facile method for somatic, lifelong manipulation of multiple genes in the mouse liver

✍ Scribed by Wangensteen, Kirk J. (author);Wilber, Andrew (author);Keng, Vincent W. (author);He, Zhiying (author);Matise, Ilze (author);Wangensteen, Laura (author);Carson, Corey M. (author);Chen, Yixin (author);Steer, Clifford J. (author);McIvor, R. Scott (author);Largaespada, David A. (author);Wang, Xin (author);Ekker, Stephen C. (author)

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
983 KB
Volume
47
Category
Article
ISSN
0270-9139

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## Abstract Hepatocellular carcinoma (HCC) is the fifth common cancer in the world and it mainly occurs in men. Glycine __N__‐methyltransferase (GNMT) participates in one‐carbon metabolism and affects DNA methylation by regulating the ratio of __S__‐adenosylmethionine to __S__‐adenosylhomocystine.