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A facile conversion of epoxides to β-halohydrins with silica gel-supported lithium halides

✍ Scribed by Hiyoshizo Kotsuki; Tomoyasu Shimanouchi


Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
196 KB
Volume
37
Category
Article
ISSN
0040-4039

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Facile conversion of epoxides to β-hydro
✍ James A. Ciaccio; Catherine Stanescu; Jongnic Bontemps 📂 Article 📅 1992 🏛 Elsevier Science 🌐 French ⚖ 236 KB

Functionalir@d epoxides are easily and efficiently converted lo P-hydroxy nitnles In good yield with high fegio-and stereoselectivity upon treatment with lithium cyanide in rcfluxing anhydrous THF The conditions described permit a one-pot conversion of epoxide to 1 J-amino alcohol via hydnde reducti