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A facile approach to norbornene-annulated cyclopentenones, a novel class of tricyclodecadienones

โœ Scribed by Jie Zhu; Antonius J.H Klunder; Binne Zwanenburg


Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
919 KB
Volume
51
Category
Article
ISSN
0040-4020

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A facile and efficient synthetic approac
โœ Ashraf A. Abbas; Ahmed H. M. Elwahy; Ahmed A. M. Ahmed ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› Journal of Heterocyclic Chemistry ๐ŸŒ English โš– 152 KB

The hydroxy macrocycles 8, 19a-c were prepared in 40-55% yields by reacting the dipotassium salts 2a-c with each of epichlorohydrin (7) and bis(chloromethyl) derivative 18. Acylation of the hydroxyl group of each of 8, 19a-c with 2-chloroacetylchloride (9) in DMF gave the corresponding esters 10, 20