✦ LIBER ✦

A facile and efficient synthesis of N-substituted furo[3,4-b]indeno[2,1-e]pyridine analogues of azapodophyllotoxin via microwave-assisted multicomponent reactions

✍ Scribed by Feng Shi; Ge Zhang; Yan Zhang; Ning Ma; Bo Jiang; Shu-Jiang Tu

Book ID: 102342010
Publisher: Journal of Heterocyclic Chemistry
Year: 2009
Tongue: English
Weight: 103 KB
Volume: 46
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.187

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✦ Synopsis

Abstract

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The efficient and facile synthesis of N‐substituted furo[3,4‐b]indeno[2,1‐e]pyridine analogues of azapodophyllotoxin was achieved via microwave‐assisted multicomponent reactions of aldehyde, 2__H__‐indene‐1,3‐dione and 4‐(arylamino)furan‐2(5__H__)‐one in glycol without catalyst. This method has the obvious advantages over traditional heating ones on short reaction time, high yield, operational simplicity as well as being environmental friendly. J. Heterocyclic Chem., (2009).

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