A Facile and Efficient Synthesis of Dihydroisobenzofuran Derivatives via Tandem Palladium-Catalyzed Coupling, Propargyl-Allenyl Rearrangement, [4+2] Cycloaddition and Aromatization Reaction

✍ Scribed by Ruwei Shen; Xian Huang; Lingzhu Chen

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 173 KB
• Volume: 350
• Category: Article
• ISSN: 1615-4150
• DOI: 10.1002/adsc.200800470

✦ Synopsis

Abstract

A variety of dihydroisobenzofuran derivatives has been prepared in good yields via an interesting sequential reaction consisting of palladium‐catalyzed coupling, propargyl‐allenyl rearrangement, [4+2] cycloaddition and aromatization. A double‐coupling, rearrangement, [4+2] cycloaddition and aromatization process is also described for the synthesis of more complex and diverse structures.