A Facile and Efficient One-Pot Synthesis of Thiochromans from Bis(2-formylphenyl) Disulfide and Alkenols via Iodine-Promoted Generation and Subsequent Intramolecular Cycloaddition of ortho-Thiobenzoquinone Methides.

A facile and efficient one-pot synthesis

A facile and efficient one-pot synthesis of thiochromans from bis(2-formylphenyl) disulfide and alkenols via iodine-promoted generation and subsequent intramolecular cycloaddition of ortho-thiobenzoquinone methides

✍ Takao Saito; Takahiro Horikoshi; Takashi Otani; Yosuke Matsuda; Takayuki Karakas 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 128 KB

Stereoselective synthesis of tetrahydrofuro-and tetrahydropyrano[3,2-c] benzothiopyrans was achieved by intramolecular [4+2]cycloaddition of o-thiobenzoquinone methides that were generated in situ from bis(2-formylphenyl) disulfide and alkenols in the presence of iodine under mild reaction conditio