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A facile and convenient method for the preparation of macrocyclic diamides

✍ Scribed by Hashem Sharghi; Khodabakhsh Niknam; Ahmad Reza Massah

Book ID
102341321
Publisher
Journal of Heterocyclic Chemistry
Year
1999
Tongue
English
Weight
407 KB
Volume
36
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

A number of macrocyclic diamides have been synthesized from the reaction of a diacid dicarboxylic dichloride with primary diamino compound in the presence of magnesium oxide‐silica gel at room temperature in good yields. Using urea and thiourea as well as diamines to produce the corresponding macrocycles in the range of 52–56% yields are also included in this paper. One of the major advantages of this method is simple regeneration of inorganic solid and its reuse through several cycles without a decrease in activity.

πŸ“œ SIMILAR VOLUMES

A facile and efficient synthetic approac
A facile and efficient synthetic approach to novel lariat macrocyclic diamides and bis macrocyclic diamides
✍ Ashraf A. Abbas; Ahmed H. M. Elwahy; Ahmed A. M. Ahmed πŸ“‚ Article πŸ“… 2005 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 152 KB

The hydroxy macrocycles 8, 19a-c were prepared in 40-55% yields by reacting the dipotassium salts 2a-c with each of epichlorohydrin (7) and bis(chloromethyl) derivative 18. Acylation of the hydroxyl group of each of 8, 19a-c with 2-chloroacetylchloride (9) in DMF gave the corresponding esters 10, 20