A Drosophila model of Parkinson's disease

High doses of nicotinamide prevent oxida

High doses of nicotinamide prevent oxidative mitochondrial dysfunction in a cellular model and improve motor deficit in a Drosophila model of Parkinson's disease

✍ Haiqun Jia; Xin Li; Hongxiang Gao; Zhihui Feng; Xuesen Li; Lei Zhao; Xu Jia; Hon 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 287 KB 👁 1 views

## Abstract Nicotinamide, the principal form of niacin (vitamin B3), has been proposed to be neuroprotective in Parkinson's disease. However, the effects and mechanisms of nicotinamide on motor function in animals and on mitochondrial function in cellular systems have not been well studied. We hypo

Parkinson's Disease Volume 504 || Drosop

Parkinson's Disease Volume 504 || Drosophila Models for Parkinson's Disease Research

✍ Bonini, Nancy M. 📂 Article 📅 2008 🏛 Elsevier 🌐 English ⚖ 31 KB

Parkinson’s disease is the second most prevalent neurodegenerative disease and is characterized by the irreversible loss of dopamine neurons. Despite its high prevalence in society and many decades of research, the origin of the pathogenesis and the molecular determinants involved in the disorder ha

Parkinson's disease: a model dilemma

✍ Beal, M. Flint 📂 Article 📅 2010 🏛 Nature Publishing Group 🌐 English ⚖ 363 KB

Modeling Parkinson's disease

✍ C. Warren Olanow; Jeffrey H. Kordower 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 68 KB 👁 2 views

Models of Parkinson's disease

✍ Michael Orth; Sarah J. Tabrizi 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 89 KB

## Abstract Parkinson's disease (PD) is a heterogenous disease likely to be caused by more than one specific aetiological factor. In rare familial cases of PD with similar clinical features to the idiopathic form of the disease, the underlying genetic cause has been identified. These PD‐associated

Parkinson's Disease Volume 9 || Caenorha

Parkinson's Disease Volume 9 || Caenorhabditis Elegans Models of Parkinson's Disease

✍ Nass, Richard 📂 Article 📅 2008 🏛 Elsevier 🌐 English ⚖ 31 KB

Parkinson’s disease is the second most prevalent neurodegenerative disease and is characterized by the irreversible loss of dopamine neurons. Despite its high prevalence in society and many decades of research, the origin of the pathogenesis and the molecular determinants involved in the disorder ha