## Communicated by Albert de la Chapelle Adenomatous polyposis coli (APC) gene transcripts skipping exon 14 in combination with the alternatively spliced exons 9 and 10A contribute to the heterogeneity of physiological APC mRNA isoforms. Here we report on a novel genotype-phenotype correlation in
β¦ LIBER β¦
A dramatic case of early-onset familial adenomatous polyposis
β Scribed by R Auricchio; M De Rosa; L Quaglietta; E Miele; G Boccia; A Staiano; P Izzo
- Book ID
- 110888007
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 213 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0009-9163
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In an effort to generate a good mouse model for human colorectal cancer, we generated mice which carry a mutation in the adenomatous polyposis coli (Apc) gene. Mice which are heterozygous for the mutation, designated Apc1638, develop colonic polyps and tumors of the small intestine. Neoplasms were f