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A Double-Blind Study of the Sedative Effects of the Thalidomide Enantiomers in Humans

✍ Scribed by Peter Höglund; Tommy Eriksson; Sven Björkman

Book ID
110402898
Publisher
Springer
Year
1998
Tongue
English
Weight
947 KB
Volume
26
Category
Article
ISSN
1573-8744

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Stereospecific determination, chiral inv
Stereospecific determination, chiral inversion in vitro and pharmacokinetics in humans of the enantiomers of thalidomide
✍ Tommy Eriksson; Sven Bjöurkman; Bodil Roth; Årsa Fyge; Peter Höuglund 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 847 KB

The purposes of this work were (1) to develop a high performance liquid chromatographic (HPLC) assay for the enantiomers of thalidomide in blood, (2) to study their inversion and degradation in human blood, and (3) to study the phannacokinetics of (+)-(R)and (-)-(S)-thalidomide after oral administra