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A double-blind, placebo-controlled trial of memantine in age-associated memory impairment (memantine in AAMI)

✍ Scribed by Steven Ferris; Lon Schneider; Mildred Farmer; Gary Kay; Thomas Crook

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
293 KB
Volume
22
Category
Article
ISSN
0885-6230

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Objectives

To determine the safety and efficacy of memantine in treating Age‐Associated Memory Impairment (AAMI).

Methods

Sixty adults between 50–79 years of age meeting diagnostic requirements for AAMI were randomly assigned to either memantine (titrated to 20 mg) or a matched placebo and treated for 90 days. An extensive battery of computerized cognitive tests was administered at screening, baseline and, thereafter, at monthly intervals.

Results and Conclusion

Study results suggest that the primary cognitive effects of memantine in this population are on attention and information processing speed, rather than on memory. There were no differences in adverse events between memantine and placebo. Copyright Β© 2006 John Wiley & Sons, Ltd.

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