✦ LIBER ✦

A double-blind, placebo-controlled study of anti-CD5 immunoconjugate in patients with rheumatoid arthritis

✍ Scribed by Nancy J. Olsen; Raye H. Brooks; John J. Cush; Peter E. Lipsky; E. William St. Clair; Eric L. Matteson; Kenneth N. Gold; Grant W. Cannon; Christopher G. Jackson; W. Joseph McCune; Betty Nelson; Todd Lorenz; Vibeke Strand

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 654 KB
Volume: 39
Category: Article
ISSN: 0004-3591
DOI: 10.1002/art.1780390705

No coin nor oath required. For personal study only.

✦ Synopsis

Objective. To evaluate the efficacy of an antLCD5 ricin-linked immunoconjugate (CD5-IC) in patients with rheumatoid arthritis (RA).

Methods. A total of 104 evaluable patients were enrolled in a multicenter, double-blind, multiple-dose, placebo-controlled study of CDS-IC.

Results. Treatment with CDS-IC in doses up to 8 mg/m2/day for 4 days in 1 month failed to produce marked or prolonged T cell depletion and was no more

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