A dose-response comparison between methadone and morphine self-administration
โ Scribed by Toreen E. Werner; Stanley G. Smith; W. Marvin Davis
- Book ID
- 104917871
- Publisher
- Springer
- Year
- 1976
- Tongue
- English
- Weight
- 225 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0033-3158
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## BACKGROUND. When a change of opioid is considered, equianalgesic dose tables are used. These tables generally propose a dose ratio of 5:l between morphine and hydromorphone. In the case of a change from subcutaneous hydromorphone to methadone, dose ratios ranging from 1:6 to 1:10 are proposed.
## Background: Current equianalgesic reference tables, based largely on single dose studies, give dose ratios of 1:1 to 4:1 for oral morphine to oral methadone, which possibly are inaccurate in patients with cancer pain who are exposed to multiple doses of these opioids. the purpose of this study w