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A dominant mutation (SAD) bypassing the requirement for the a mating type locus in yeast sporulation

✍ Scribed by Kassir, Yona ;Herskowitz, Ira

Publisher: Springer
Year: 1980
Tongue: English
Weight: 672 KB
Volume: 180
Category: Article
ISSN: 0026-8925
DOI: 10.1007/bf00425843

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✦ Synopsis

SAD (suppressor of a deficiencies) is a mutation that allows c~-mater diploids such as c~/~ or al-/~ strains to sporulate. This mutation is unstable and reverts to wildtype (sad +) even in strains homozygous for SAD. SAD is dominant to sad+: ~/c~ and al /~ sad+/SAD diploids are sporulation-proficient. SAD is located on chromosome III, 40 cM distal to the mating type locus, between THR4 an~t HMRa. The ability of SAD to support sporulation requires the presence of an ~ mating type locus with an active ~2 function. Possible models for the action of SAD are (1) SAD bypasses the need fo, r al function in sporulation, and (2) SAD provides al function to MATal-mutants by supplying al function itself, for example, by allowing expression of a silent copy of MATa.

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