Dendritic cells (DCs) are potent inducers of cytotoxic T lymphocytes (CTLs) when pulsed with an antigenic peptide or tumor lysate. In this report, we have used liposomemediated gene transfer to examine the ability of plasmid DNA encoding the human melanoma-associated antigen gp100 to elicit CD8 Ψ an
β¦ LIBER β¦
A DNA vaccine co-expressing antigen and an anti-apoptotic molecule further enhances the antigen-specific CD8+ T-cell immune response
β Scribed by Tae Woo Kim; Chien-Fu Hung; Meizi Zheng; David A. K. Boyd; Liangmei He; Sara I. Pai; T. C. Wu
- Publisher
- BioMed Central
- Year
- 2004
- Tongue
- English
- Weight
- 731 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1021-7770
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## Abstract ## Background DNA vaccines have been shown to be an effective approach to induce antigenβspecific cellular and humoral immunity. However, the lower immune intensity in clinical trials limits the application of DNA vaccine. Here we intend to develop a new DNA vaccine based on prostate s