## Abstract **Background:** The inhibition of DNA replication fork progression by DNA lesions can lead to cell death or genome instability. However, little is known about how such DNA lesions affect the concurrent synthesis of leadingβ and laggingβstrand DNA catalysed by the protein machinery used
A DNA replication origin and a replication fork barrier used in vivo in the circular plasmid pKD1
β Scribed by L. Fabiani; C. Irene; M. Aragona; C. Newlon
- Book ID
- 106133543
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 232 KB
- Volume
- 266
- Category
- Article
- ISSN
- 1617-4615
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## Abstract To prevent duplicate DNA synthesis, metazoan replication origins are licensed during G1. Only licensed origins can initiate replication, and the cytoplasm interacts with the nucleus to inhibit new licensing during S phase. DNA replication in the mammalian oneβcell embryo is unique becau