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A DNA-Damage Selective Role for BRCA1 E3 Ligase in Claspin Ubiquitylation, CHK1 Activation, and DNA Repair

✍ Scribed by Ko Sato; Elayanambi Sundaramoorthy; Eeson Rajendra; Hiroyoshi Hattori; Anand D. Jeyasekharan; Nabieh Ayoub; Ralph Schiess; Ruedi Aebersold; Hiroyuki Nishikawa; Anna S. Sedukhina; Haruka Wada; Tomohiko Ohta; Ashok R. Venkitaraman


Book ID
119224591
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
942 KB
Volume
22
Category
Article
ISSN
0960-9822

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## Abstract Concurrent activation of poly (ADP‐ribose) polymerase (PARP) and DNA ligase was observed in cultured human epidermal keratinocytes (HEK) exposed to the DNA alkylating compound sulfur mustard (SM), suggesting that DNA ligase activation could be due to its modification by PARP. Using HEK,