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A divergent approach to apoptolidin and FD-891: asymmetric preparation of a common intermediate

✍ Scribed by Shu-Sin Chng; Jia Xu; Teck-Peng Loh

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 395 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(03)01173-0

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✦ Synopsis

Biologically active Apoptolidin and FD-891 have structural similarity in their macrocyclic cores. Asymmetric preparation of a common intermediate in the total synthesis of these two macrolides is presented. A modified Masuyama Sn-allylation was employed to control the relative stereochemistry in the synthesis of the intermediate.

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